介绍

氨基酸序列表征是几乎任何蛋白质分析的基本组成部分，创建简洁清晰的蛋白质拓扑结构在蛋白质组学研究中具有重要意义。尽管存在许多数据库和预测服务器，但是将来自各种资源（有时是竞争资源）的数据合并到一个准备发布的方案中是具有挑战性的。

在这里，我们展示了蛋白质拓扑设计R包（protodesigner），用于从数据库接入号、多个预测服务器的原始结果或手动准备的特征表中自动生成蛋白质拓扑方案。该应用程序提供了一个图形用户界面，在R Shiny中实现，托管Pfam的域生成器的增强版本，用于渲染视觉上吸引人的方案。

Abstract
Background
Amino acid sequence characterization is a fundamental part of virtually any protein analysis, and creating concise and clear protein topology schemes is of high importance in proteomics studies. Although numerous databases and prediction servers exist, it is challenging to incorporate data from various, and sometimes contending, resources into a publication-ready scheme.

Results
Here, we present the Protein Topology Deviser R package (ProToDeviseR) for the automatic generation of protein topology schemes from database accession numbers, raw results from multiple prediction servers, or a manually prepared table of features. The application offers a graphical user interface, implemented in R Shiny, hosting an enhanced version of Pfam’s domains generator for the rendering of visually appealing schemes.

代码

• https://github.com/Izzilab/protodeviser

案例

参考

• https://github.com/Izzilab/protodeviser