15-deoxy-Δ12,14-PGJ2（15-d-PGJ2）是PGD2的最终脱水产物之一，通过中间体Δ12-PGJ2形成。生理条件下，15-d-PGJ2存在于体液中，浓度介于10^(-12)至10^(-9)M，但在感染和炎症等应激条件下会急剧增加。在细胞类型和浓度的影响下，15-d-PGJ发挥促进和抗炎症作用，其中许多作用是通过与过氧化物酶体增殖剂激活受体（PPAR-γ）的γ异构体结合而介导的。15-d-PGJ2似乎通过一种与PPAR-γ无关的机制诱导HO-1的表达，该机制由活性氧（ROS）的产生介导。
Enzo Life Sciences的15-脱氧-Δ12,14-前列腺素J2 ELISA试剂盒是一种比色竞争法酶联免疫检测试剂盒，可在5小时内得到检测结果，相比GC/MS 分析节省时间且耗时少得多。欣博盛生物作为Enzo Life Sciences授权中国一级代理，可提供该产品，欢迎咨询。
产品特色
◆ 灵敏度高，可测量低至36.8 pg/ml的15-deoxy-Δ12,14-PGJ2
◆ 检测快速，较GC/MS分析耗时少得多
◆ 易于使用的即用型液体颜色编码试剂，可减少错误
◆ 优于半定量Western blot分析的完全定量检测
产品信息
| 产品货号 | ADI-900-023/ ADI-901-023 |
| 产品名称 | 15-deoxy-Δ12,14-PGJ2 ELISA kit(15-脱氧-Δ12,14-前列腺素J2 ELISA试剂盒)/欣博盛生物 |
| 规格 | 96 wells/ 5x96 wells |
| 其他名称 | 15-deoxy-Δ12,14-Prostaglandin J2 |
| 灵敏度 | 36.8 pg/ml |
| 检测范围 | 195 - 200,000 pg/ml |
| 检测时间 | 5 hours |
| 应用 | ELISA, Colorimetric detection |
| 检测波长 | 405 nm |
| 样本类型 | 细胞培养上清，血浆，唾液和尿液 |
| 适用种属 | 不限种属 |
| 试剂盒组分 | GxR IgG Microtiter plate, Conjugate, Antibody, Assay buffer, Wash buffer concentrate, Standard, pNpp Substrate, Stop solution |
标曲示例
部分产品引用文献
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6. Apolipoprotein D overexpression alters hepatic prostaglandin and omega fatty acid metabolism during the development of a non-inflammatory hepatic steatosis: F. Desmarais, et al.; Biochim. Biophys. Acta Mol. Cell Biol. Lipids 1864, 522 (2019)
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10. Bone-marrow-derived mesenchymal stem cells inhibit gastric aspiration lung injury and inflammation in rats: J. Zhou, et al.; J. Cell Mol. Med. 20, 1706 (2016)
11. Implications of a genetically determined nitric oxide deficit for endothelial cell-leukocyte interaction and cardiovascular disease: I. Kadiyska; (2016)
12. CRTH2 is a critical regulator of neutrophil migration and resistance to polymicrobial sepsis: M. Ishii, et al.; J. Immunol. 188, 5655 (2012)
13. Choroidal involution is a key component of oxygen-induced retinopathy: Z. Shao, et al.; Invest. Ophthalmol. Vis. Sci. 52, 6238 (2011)
14. Response of chondrocytes to shear stress: antagonistic effects of the binding partners Toll-like receptor 4 and caveolin-1: P. Wang, et al.; FASEB J. 25, 3401 (2011)
15. The myocardial infarct size-limiting effect of sitagliptin is PKA-dependent, whereas the protective effect of pioglitazone is partially dependent on PKA: Y. Ye, et al.; Am. J. Physiol. Heart Circ. Physiol. 298, H1454 (2010)
